Fully-enclosed tissue processor. The Leica ASP300 S smart, fully enclosed tissue processor is designed for routine and research histopathology. Proven technology combined with top quality components and Leica´s RemoteCare diagnostic (optional) provide superior instrument reliability. Straightforward routine user operations by an intuitive user interface, color touch screen and a variety of “smart” features, such as Reagent Management System and quick start for commonly used programs, improve specimen quality and laboratory economy.

Bench top cryostat for clinical pathology. State-of-the-art technology and perfect user friendliness characterize the large Leica cryostats – distinctive features which are also available in a compact, portable design. With the need for mobile diagnostics ever increasing, the Leica CM1100 is the ideal cryostat for safe and fast on-the-spot evaluation – at the same time it is also an excellent back-up instrument. With a total weight of only 50 kg, the Leica CM1100 can be easily carried and be transported in practically any vehicle.

Cryostat for clinical applications. The Leica CM1850 cryostat for standard applications in the clinical histopathology laboratory is designed for easy use and a high-volume workload. The insulation technology used enhances the durability of the refrigerating system and maintains stable cryochamber temperatures even when operating the instrument under unfavorable environmental conditions.

Cryostat for routine histology.The Leica CM1850 UV incorporates the proven excellent features of its predecessor - and much more. It is equipped with an optimized refrigeration system affording extremely short specimen freezing times. The cryochamber can be disinfected quickly and effectively at any time with ultra-violet light (UVC) for increased operator safety. UV surface disinfection significantly reduces the danger of infection by bacteria, spores and viruses. Leica’s new, antimicrobial nano-silver coating, AgProtect™, provides outstanding protection to cryostat users by reducing exposure to surface pathogens. Leica’s AgProtect™ covers the cryostat’s outside surfaces and protects the operator and other individuals in the work area by penetrating the membranes of microbes to prevent replication. The outstanding safety of the CM1850 UV has been tested and certified by an independent laboratory.

Research cryostat. The Leica CM3050 S cryostat was designed primarily for the demanding needs of cryosectioning systems in the field of biomedical, neuro-anatomical and pharmaceutical research. Particularly when working with delicate specimens – for example brain samples in neuroscience – the precise specimen orientation and the specimen feed system via step motor guarantees reproducible thin serial sections of maximum quality. The Leica motorized CM3050 S is available with or without active specimen cooling. An ergonomic height adjustment can be retrofitted, enabling the user to operate the cryostat in a sitting or standing position.

Robotic coverslipper. The Leica CV5030 fully automated glass coverslipper produces slides with superior optical quality for reliable long-term storage. It is designed to coverslip microscope glass slides bearing tissue sections or cytopathology smears. The capability of handling a large variety of slide racks from different suppliers makes the Leica CV5030 a most flexible instrument. All common mounting media, including xylene-free varieties, can be used according to individual operator settings. The system is capable of high-throughput coverslipping of more than 400 slides per hour using standard microscope slides and glass coverslips of different sizes. The operator can choose between wet and dry coverslipping.

Modular tissue embedding system. The Leica EG1150 modular tissue embedding center incorporates two separate components, the Leica EG1150 C cold plate and the Leica EG1150 H heated paraffin dispensing module. The independent modules offer the flexibility to arrange embedding workflow in either direction (left to right or right to left) to suit the user's needs. For orienting specimens from biopsies and other, especially very small specimens, an adjustable magnifier is available as an option.

Embedding center, dispenser + hot plate. Compact dimensions, ease of operation, and excellent standards of convenience and safety characterize the Leica EG1160 paraffin embedding station. The separately heated paraffin dispensing system of the Leica EG1160 with an integrated filter ensures constant, reproducible paraffin flow at ten different flow rate settings. All instrument functions - including the automatic starting time - are individually programmable at just the press of a button. Large and temperature-controlled hand rest areas give the user maximum freedom of movement. The Leica EG1160 offers a wide range of accessories (cold light source, vacuum attachment and magnifier).

Specimen trimming device for TEM, SEM, LM. Build a pyramid in less than 60 seconds! The Leica EM Trim2 is a high speed milling system with an integrated stereo microscope and LED ring illuminator for trimming of biological and industrial samples prior to ultramicrotomy. A pivot arm and adjustment assembly holds the specimen carrier for optimum orientation. It can be used with either tungsten carbide or diamond milling tools. The area of interest can be centered and a flat block face milled onto the front face of the sample. For TEM and LM the sample must be trimmed to shape by adjusting the angle of the pivot arm and trimming the desired block shape - pyramidal, square rectangular, etc... Viewing of the specimen perpendicular to the axis of the stereomicroscope allows distance definition i.e. from the front face of the sample. All this takes place under constant observation with the stereo microscope.

Automatic freeze substitution system. The Leica EM AFS2 is capable of freeze substitution and progressive lowering of temperature ( PLT ) techniques as well as allowing low temperature embedding and polymerization of resins. A stereomicroscope for viewing and positioning of the samples is available and the LED illumination from within the chamber makes work easy. The freeze substitution processor EM FSP is an automatic reagent handling system. Sitting on the EM AFS2, it dispenses reagents for both freeze substitution and PLT techniques.

Universal cryofixation and cryopreparation system. The modular design of the Leica EM CPC cryoworkstation facilitates quick and easy change of the cryofixation modules allowing plunge freezing of tissue into propane, bare grid method with ethane or metal mirror freezing ( slam freezing ) onto gold coated copper blocks.

Low temperature sectioning system for Leica EM UC6. The Leica EM FC6 cryochamber is designed for low temperature sectioning of biological and industrial samples at temperatures from -15 to -185°C. It sets new standards in cryosectioning, not only for TEM but also for LM, SEM and AFM. The Leica EM FC6 has been designed in accordance with customer requests for a more ergonomic, easy-to-use instrument with a wider temperature range and increased sectioning stability. Ergonomic hand rests ensure fatigue-free cryosectioning, while the integration of the EM FC6 controls in the control unit of the Leica EM UC6 saves space on the desk and the LED illumination of the chamber ensures a perfect view of the sections.

Low temperature sectioning system for Leica Ultracut UCT. Low temperature sectioning system for biological and industrial samples at temperatures as low as -185°C. The FCS fits onto the Ultracut UCT, Ultracut R and Ultracut S becoming an integral part of the instrument. Sections can be made on either glass or diamond knives, the knife holder accommodating both plus a trimming tool. Features include: contact free, through-the-wall, specimen holder system, open top design with no cover allowing easy access and no disturbing ice-condensation. Warmed external surfaces for operator comfort. Memory for 3x3 settings of knife, specimen and gas temperature. Accurate control of specimen, knife and chamber gas temperature. Alignment of knife with self-locking drives from outside the chamber.

The first automated immunogold labeling system, the innovative Leica EM IGL, sets a new industry standard by automating the tedious, time-consuming manual process of immunogold labeling. The Leica EM IGL offers many advantages such as the simultaneous labeling of 24 grids as well as the ability to use up to 24 different primary antibodies in one run. Automation with the EM IGL saves up to 80 % of the user's time, thus saves costs and frees technicians for more productive activities. Specimen safety is ensured by applying the correct sequence of reagents and minimizing cross contamination from forceps and loops during labeling. Reproducible results can be achieved time after time as the EM IGL follows the exact incubation times specified in the protocol.

The Leica EM KMR2 glass knifemaker produces 45° glass knives from 6.4, 8 and 10 mm thick glass utilizing the balanced-break method. This method begins with a standard 400 mm long glass strip in any of the three thicknesses and continuously breaks the strip into equal halves. You then have a number of flat sided squares perfect for making 45° knives suitable for light and electron microscopy applications. Accessories include knife boxes, scoring wheels and trufs, the ultramicrotomist's standard boat for glass knives.

The Leica EM MM80 E Metal Mirror Cryofixation system consists of an LN2 cooled gold coated, highly pure copper block used for the impact freezing (slam freezing) of samples such as tissues and cell suspensions to form a vitreous ice layer (vitrification) for freeze substitution and subsequent Transmission Electron Microscopy (TEM). This instrument ensures high quality results with simple operation, low initial costs, and low operating expense. In standby mode it uses less than 1 liter LN2/hour. The heating cycle automatically switches off after use.

Multi-Heating Plate The Leica EM MP multiplate (hotplate) features three different temperatures for mounting Trufs onto glass knives, drying semithin sections on glass slides and staining semithin sections. A perfect tool for the specimen preparation lab

The Leica EM PACT2 High Pressure Freezer is the first step in the preparation of samples for many subsequent techniques, allowing high quality freezing up to 200 µm into the specimen. The instrument only needs to be connected to a standard power supply and comes with its own compressor located on the same trolley making it fully mobile. The Rapid Transfer System EM RTS is an accessory to Leica EM PACT2. It allows an ease of sample preparation never before experienced in the field of High Pressure Freezing. Place your sample in the flat carrier held in the fork and simply push it into the instrument. The EM RTS does the rest. It takes the sample, locks it into the pod and shoots it into the Leica EM PACT2 where it is frozen - all in less than 2.5 seconds!

Automated Routine Tissue Processor Station With the Leica EMTP tissues can be processed into resin for subsequent EM and LM analysis. The Tissue Pro- cessor has an exhaust system allowing safe use of toxic substances such as osmium. Individual seals reduce evapo- ration of reagents while the pre heat/cool system allows the correct reagent temperature to be maintained throughout processing. Small vials are available for EM processing and larger for LM which can also be used for high throughput EM runs utilizing the Tripod system where over 150 EM samples can be processed in one run.